Epigenetics & Chromatin
DNA is wrapped around an octamer of histone proteins to form chromatin, then packaged into chromosomes by other structural proteins. The organization of genetic material in the nucleus has profound effects on all processes that require access to DNA. These processes must be tightly regulated to maintain the integrity of the genome. However, chromatin and chromosomes undergo dramatic and dynamic changes in organization in response to a myriad of signals that are critical to cell function. The field of epigenetics involves the study of chromatin-based phenomena and heritable changes in gene expression not resulting from changes in gene structure or sequence.
Much of the regulation of the genome involves the histone proteins that are the core of chromatin and chromosome structure. Histone modifications (e.g. acetylation, methylation, phosphorylation) and DNA methylation at CpG islands are part of the mechanisms by which genome function is regulated. Protein effectors recognize and bind to specific histone modifications. Similarly, the MBD family of proteins bind methylated stretches of DNA and have important interactions with other chromatin-associated proteins that lead to downstream regulatory effects.
Active Motif is committed to helping researchers study these important events through the development of high-quality products centered on chromatin biology and epigenetics.
- Chromatin IP Kits and reagents
- Kits to study DNA damage, DNA methylation and histone modifications
- High-quality antibodies to histones and chromatin proteins